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2008 2
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17 results

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miRNA-218/FANCI is associated with metastasis and poor prognosis in lung adenocarcinoma: a bioinformatics analysis.
Ye G, Liu Y, Huang L, Zhang C, Sheng Y, Wu B, Wu C, Qi Y. Ye G, et al. Ann Transl Med. 2021 Aug;9(16):1298. doi: 10.21037/atm-21-3823. Ann Transl Med. 2021. PMID: 34532435 Free PMC article.
We also explored whether the FANCI was related to immune cell infiltration in LUAD. RESULTS: FANCI was identified as a hub gene and associated with poor OS. We found that miR-218 negatively regulates FANCI mRNA expression. At the mRNA expression and protein l …
We also explored whether the FANCI was related to immune cell infiltration in LUAD. RESULTS: FANCI was identified as a hub gen …
High expression levels of FANCI correlate with worse prognosis and promote tumor growth of lung adenocarcinoma partly via suppression of M1 macrophages.
Li W, Yu M, Zhang J, Huang J, Lin Z, Chen J, Jiang G, Lin X. Li W, et al. Gene. 2023 Jan 30;851:147053. doi: 10.1016/j.gene.2022.147053. Epub 2022 Nov 14. Gene. 2023. PMID: 36395972
However, the correlation of FANCI with prognostic value and the molecular mechanism in patients with lung adenocarcinoma (LUAD) remains unclear. ...Importantly, the overexpression of FANCI significantly inhibited the activation of M1 macrophages. All the data …
However, the correlation of FANCI with prognostic value and the molecular mechanism in patients with lung adenocarcinoma (LUAD …
Aberrant R-loop-mediated immune evasion, cellular communication, and metabolic reprogramming affect cancer progression: a single-cell analysis.
Zhang S, Liu Y, Sun Y, Liu Q, Gu Y, Huang Y, Zeng Z, Tang F, Ouyang Y. Zhang S, et al. Mol Cancer. 2024 Jan 10;23(1):11. doi: 10.1186/s12943-023-01924-6. Mol Cancer. 2024. PMID: 38200551 Free PMC article.
In this study, using single-cell RNA-sequencing datasets from lung adenocarcinoma (LUAD), we constructed an R-loop scoring model to characterize the R-loop state according to the identified R-loop regulators related to EGFR mutations, tissue origins, and TNM stage. We then …
In this study, using single-cell RNA-sequencing datasets from lung adenocarcinoma (LUAD), we constructed an R-loop scoring model to c …
FANCI Cooperates with IMPDH2 to Promote Lung Adenocarcinoma Tumor Growth via a MEK/ERK/MMPs Pathway.
Zheng P, Li L. Zheng P, et al. Onco Targets Ther. 2020 Jan 15;13:451-463. doi: 10.2147/OTT.S230333. eCollection 2020. Onco Targets Ther. 2020. PMID: 32021289 Free PMC article.
PURPOSE: Fanconi anemia complementation group I (FANCI) is a key protein in ribosome biogenesis and DNA repair. Here, we aimed to determine the clinical significance, prognostic value and biology functions of FANCI in lung adenocarcinoma (LUAD). ...RESULTS: …
PURPOSE: Fanconi anemia complementation group I (FANCI) is a key protein in ribosome biogenesis and DNA repair. Here, we aimed to det …
TXNL4B regulates radioresistance by controlling the PRP3-mediated alternative splicing of FANCI.
Ju Z, Xiang J, Xiao L, He Y, Zhang L, Wang Y, Lei R, Nie Y, Yang L, Miszczyk J, Zhou P, Huang R. Ju Z, et al. MedComm (2020). 2023 May 7;4(3):e258. doi: 10.1002/mco2.258. eCollection 2023 Jun. MedComm (2020). 2023. PMID: 37168687 Free PMC article.
Here, we reported that the spliceosomal protein thioredoxin-like 4B (TXNL4B) is highly expressed in lung tissues from lung cancer patients with radiotherapy. Lung cancer cells with TXNL4B knockdown illustrate increased sensitivity to IR. ...Nuclear localizati …
Here, we reported that the spliceosomal protein thioredoxin-like 4B (TXNL4B) is highly expressed in lung tissues from lung can …
UBE2T regulates FANCI monoubiquitination to promote NSCLC progression by activating EMT.
Zhang J, Wang J, Wu J, Huang J, Lin Z, Lin X. Zhang J, et al. Oncol Rep. 2022 Aug;48(2):139. doi: 10.3892/or.2022.8350. Epub 2022 Jun 15. Oncol Rep. 2022. PMID: 35703356 Free PMC article.
Fanconi anemia complementation group I (FANCI) is a critical protein for maintaining DNA stability. However, the exact role of FANCI in tumors remains to be elucidated. The present study aimed to explore the role and potential mechanism of action of FANCI in …
Fanconi anemia complementation group I (FANCI) is a critical protein for maintaining DNA stability. However, the exact role of FAN …
Oncogenic HPV promotes the expression of the long noncoding RNA lnc-FANCI-2 through E7 and YY1.
Liu H, Xu J, Yang Y, Wang X, Wu E, Majerciak V, Zhang T, Steenbergen RDM, Wang HK, Banerjee NS, Li Y, Lu W, Meyers C, Zhu J, Xie X, Chow LT, Zheng ZM. Liu H, et al. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2014195118. doi: 10.1073/pnas.2014195118. Proc Natl Acad Sci U S A. 2021. PMID: 33436409 Free PMC article.
Both genes are up-regulated in HPV lesions and in in vitro model systems of HR-HPV18 infection. We observe a moderate reciprocal regulation of lnc-FANCI-2 and FANCI in cervical cancer CaSki cells. In these cells, lnc-FANCI-2 is transcribed from two alternativ …
Both genes are up-regulated in HPV lesions and in in vitro model systems of HR-HPV18 infection. We observe a moderate reciprocal regulation …
Inactivation of ribosomal protein S27-like impairs DNA interstrand cross-link repair by destabilization of FANCD2 and FANCI.
Sun S, He H, Ma Y, Xu J, Chen G, Sun Y, Xiong X. Sun S, et al. Cell Death Dis. 2020 Oct 13;11(10):852. doi: 10.1038/s41419-020-03082-9. Cell Death Dis. 2020. PMID: 33051438 Free PMC article.
Whether and how RPS27L modulates DNA interstrand cross-link (ICL) repair is unknown. Here we identified that RPS27L binds to FANCD2 and FANCI, two Fanconi anemia (FA) proteins functioning in ICL repair pathway. ...Together, our study shows that RPS27L positively regulates …
Whether and how RPS27L modulates DNA interstrand cross-link (ICL) repair is unknown. Here we identified that RPS27L binds to FANCD2 and F …
ATM participates in fine particulate matter-induced airway inflammation through regulating DNA damage and DNA damage response.
Jin Y, Li Y, He S, Ge Y, Zhao Y, Zhu K, He A, Li S, Yan S, Cao C. Jin Y, et al. Environ Toxicol. 2023 Nov;38(11):2668-2678. doi: 10.1002/tox.23901. Epub 2023 Jul 23. Environ Toxicol. 2023. PMID: 37483094
The results show that, following exposure to PM2.5, the number of neutrophils in broncho alveolar lavage fluid and the mRNA expression of CXCL-1 in lung tissues of the ATM(+/-) mice were lower than those of the WT mice. The mRNA expression of FANCD2 and FANCI were a …
The results show that, following exposure to PM2.5, the number of neutrophils in broncho alveolar lavage fluid and the mRNA expression of CX …
Identifying the hub genes in non-small cell lung cancer by integrated bioinformatics methods and analyzing the prognostic values.
Wang T, Chen X, Jing F, Li Z, Tan H, Luo Y, Shi H. Wang T, et al. Pathol Res Pract. 2021 Dec;228:153654. doi: 10.1016/j.prp.2021.153654. Epub 2021 Oct 13. Pathol Res Pract. 2021. PMID: 34749208
BACKGROUND: Lung cancer, a malignant tumor, has the highest mortality and second most common morbidity worldwide. Non-small cell lung cancer (NSCLC) is the most common pathological subtype of lung cancer. ...
BACKGROUND: Lung cancer, a malignant tumor, has the highest mortality and second most common morbidity worldwide. Non-small cell l …
17 results